Здравствуйте!
Подскажите, плиз, вероятность прохождения реакции только по одной ОН-группе в молекуле глицерина. И если реакция пройдет по одной из гидроксильных групп, то по какой?
Методика вот эта:
To prepare 2hydroxyethyl 2chloropropionate, etylene glycol (12.4 g, 0.20 mol) was dissolved in 20 mL anhydrous THF, then Na2CO3 (4.2 g, 0.04 mol)
was added and cooled in an ice bath. After 15 min, 2chloropropionyl chloride (5.07 g, 0.04 mol) dissolved in 5 mL of anhydrous THF was added dropwise
over 20 min. The reaction was stirred at 5°C for 30 min and then at room temperature for overnight. The reaction mixture was filtered; THF was removed on a
rotary evaporator. The reaction mixture was diluted with water and extracted with dichloromethane (10 mL ×3). 2Hydroxyethyl 2chloropropionate was
dried over Mg2SO4and dichloromethane was removed on a rotary evaporator.